Extractables and leachables (E&L) testing is a critical part of ensuring product quality in a wide range of application areas, specifically those where goods may go on to have a profound impact on human health. Food contact materials, medical devices, and pharmaceuticals are among the most stringently controlled goods from an E&L perspective. Yet it is still common to conduct E&L testing using relative quantitation and surrogate standards, due to the sheer diversity of observable species and the lack of effective reference standards.
A common problem arising from the inherent drawbacks of conventional E&L testing is the variability of response factors (RF). Different compounds at identical concentrations may give different signal intensities, thus exhibiting differential RF values. This may impact quantitative accuracy, as well as corresponding toxicological risk assessments.
At Jordi Labs, we have explored a range of methods for mitigating RF variation and thus the need for uncertainty factors in E&L testing. In our latest publication, we show how to reduce RF variation using a multidetector approach to E&L testing, yielding greater accuracy and mitigating the need for uncertainty factors.
E&L Testing with Jordi Labs
Jordi Labs is the leading authority on E&L testing. Download our publication using the link below and contact a member of the team if you would like more information about the multidetector approach.